First 3D colour x-ray of a human using CERN technology

What if, instead of a black and white X-ray picture, a doctor of a cancer patient had access to colour images identifying the tissues being scanned? This colour X-ray imaging technique could produce clearer and more accurate pictures and help doctors give their patients more accurate diagnoses.

Professor Anthony Butler (left) and his father Professor Phil Butler have built the MARS spectral CT scanner. University of Canterbury in NZ Herald

Romain Muller, CERN 10 July 2018This is now a reality, thanks to a New-Zealand company that scanned, for the first time, a human body using a breakthrough colour medical scanner based on the Medipix3 technology developed at CERN. Father and son scientists Professors Phil and Anthony Butler from Canterbury and Otago Universities spent a decade building and refining their product.

Timepix3, one of the read-out chips of Medipix. CERN

Medipix is a family of read-out chips for particle imaging and detection. The original concept of Medipix is that it works like a camera, detecting and counting each individual particle hitting the pixels when its electronic shutter is open. This enables high-resolution, high-contrast, very reliable images, making it unique for imaging applications in particular in the medical field.

Hybrid pixel-detector technology was initially developed to address the needs of particle tracking at the Large Hadron Collider, and successive generations of Medipix chips have demonstrated over 20 years the great potential of the technology outside of high-energy physics.

Ankle colour x-ray imaged by the Medipix All Resolution System, MARS Bioimaging Ltd.

MARS Bioimaging Ltd, which is commercialising the 3D scanner, is linked to the Universities of Otago and Canterbury. The latter, together with more than 20 research institutes, forms the third generation of the Medipix collaboration. The Medipix3 chip is the most advanced chip available today and Professor Phil Butler recognises that “this technology sets the machine apart diagnostically because its small pixels and accurate energy resolution mean that this new imaging tool is able to get images that no other imaging tool can achieve.”

MARS’ solution couples the spectroscopic information generated by the Medipix3 enabled detector with powerful algorithms to generate 3D images. The colours represent different energy levels of the X-ray photons as recorded by the detector and hence identifying different components of body parts such as fat, water, calcium, and disease markers.

A 3D image of a wrist with a watch showing part of the finger bones in white and soft tissue in red. MARS Bioimaging Ltd.

So far, researchers have been using a small version of the MARS scanner to study cancer, bone and joint health, and vascular diseases that cause heart attacks and strokes. “In all of these studies, promising early results suggest that when spectral imaging is routinely used in clinics it will enable more accurate diagnosis and personalisation of treatment,” Professor Anthony Butler says.

CERN’s Knowledge Transfer group has a long-standing expertise in transferring CERN technologies, in particular for medical applications. In the case of the 3D scanner, a licence agreement has been established between CERN, on behalf of the Medipix3 collaboration and MARS Bioimaging Ltd. As Aurélie Pezous, CERN Knowledge Transfer Officer states: “It is always satisfying to see our work leveraging benefits for patients around the world. Real-life applications such as this one fuels our efforts to reach even further.”

In the coming months, orthopaedic and rheumatology patients in New Zealand will be scanned by the revolutionary MARS scanner in a clinical trial that is a world first, paving the way for a potentially routine use of this new generation equipment.

Source CERN, Conseil Européen pour la Recherche Nucléaire

Molecular imaging without radiotracers. MARS promises to revolutionize diagnostic imaging by quantifying the elements and compounds of a sample in a single scan. It is the first commercially available 3D spectral (multi-energy) scanner to produce in vivo images with anatomic and molecular quantification at a fraction of the cost, time, and radiation dose of traditional molecular imaging, such as PET or SPECT.

The Medipix spectral x-ray detector technology was originally developed at CERN for the LHC and modified for medical applications; it is the result of 20+ years of collaborative innovation. James Bennett. Published on Youtube Sep 1, 2015.

Also see
New Zealand scientists perform first-ever 3D, Colour X-Ray on a human in Healthcare.Digital
Kiwi 3D scanner could revolutionise x-ray, detect disease in NZ Herald
What a mouse teaches us about the future of 3D color x-rays in Wired

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